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In March 2020 the MHRA issued a reminder notice highlighting the dangers associated with co-prescribing of benzodiazepines (B-Zs) and opioids. This was prompted by a coroner’s report following the death of a man prescribed clonazepam and, among other drugs, the opioid methadone. His death was attributed to the combination causing respiratory depression.
The GGC clinical guideline Opioid prescribing for chronic non-malignant pain advises “do not prescribe opioids to patients currently taking B-Zs”. Co-prescribing has additive effects in the central nervous system (CNS) leading to increased sedation, impaired alertness, reduced motor response and respiratory depression.
Despite the risks, Torrance et al 2018 found opioid prescribing in Scotland was increasing and co- prescribing of B-Zs was common.