Greater Glasgow and Clyde Medicines

Latest Medicines Updates & News -2011

19: Clopidogrel and PPIs

Posted: Friday, November 4, 2011

Category - Medicines Update Extra

 

Clopidogrel and Possible Interaction with Proton Pump Inhibitors

  • It is still not clear whether there is definitely a clinically relevant interaction between PPIs and clopidogrel as
    available data are conflicting.
  • Although there is extrapolation from in vitro studies that some PPIs may be less likely to interact with
    clopidogrel there does not appear to be any evidence from clinical practice that any one PPI is better than
    another in this respect.
  • Prescribers should consider the risk of GI side effects versus the risk of adverse cardiac events when
    considering co-prescription of a PPI and clopidogrel.
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