Greater Glasgow and Clyde Medicines

Latest Medicines Updates & News

Metformin and reduced vitamin B12 levels

Posted: Monday, November 14, 2022

Category - Medicines Update

  • Metformin can commonly reduce vitamin B12 levels in patients, which may lead to vitamin B12 deficiency. Refer to MHRA Drug Safety Update here.

  • B12 deficiency risk increases with higher metformin doses, longer treatment duration and patients with a risk of B12 deficiency (see below for additional risk factors)

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