Greater Glasgow and Clyde Medicines

Medicines Update -2023

GGC Medicines Update is a series of blogs with important medicines related messages relevant to all healthcare professionals across GGC.

Please note, Medicines Update blogs are correct at the time of publication.

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Proton pump inhibitors (PPIs): potential link with Clostridioides difficile infection and pneumonia

Posted: Wednesday, January 4, 2023

Category - Medicines Update

  • Clostridioides difficile infection (CDI) has been associated with PPI use.
  • The NHSGGC guideline on Management of Suspected or Proven Clostridioides difficile Infection (CDI) in Adults advises stopping gastric acid suppression (e.g. PPIs) where possible.

  • In recent years there have been reports of a link between PPI use and pneumonia, however, evidence is conflicting and therefore there are no NHSGGC guidelines for the management of PPIs in patients with pneumonia.

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