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Metformin can commonly reduce vitamin B12 levels in patients, which may lead to vitamin B12 deficiency. Refer to MHRA Drug Safety Update here.
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B12 deficiency risk increases with higher metformin doses, longer treatment duration and patients with a risk of B12 deficiency (see below for additional risk factors)
Metformin and reduced vitamin B12 levels
Posted: Monday, November 14, 2022
Category - Medicines Update