5.1.7. Some other antibacterials
Restrictions:
Restricted to specialist initiation where nebulised colistimethate is not tolerated and tobramycin is being considered.
Restrictions:
For restrictions please see prescribing notes below
Prescribing Notes:
- Restricted to specialist initiation. Restricted to use on microbiological and infectious disease physician advice only.
Restrictions:
Restricted to specialist initiation by a microbiologist or specialist in infectious diseases. Restricted to use in patients not responding to or intolerant of a glycopeptide, or those with microbiological cultures which indicate glycopeptide resistance.
Prescribing Notes:
Please note, this is a PROTECTED ANTIBIOTIC (see policy here) and relevant paper work should be completed.
For daptomycin dosing in adults click here
Restrictions:
Fidaxomicin is restricted to use for the treatment of adults with microbiologically proven recurrence of Clostridium difficile infection (CDI) only on the advice of Consultant microbiologists or Consultants in Infectious Diseases.
Please note: this is a PROTECTED ANTIBIOTIC (see policy here) and relevant paper work should be completed.
It is non-formulary for use in adults with first episode of CDI or as empirical treatment in CDI.
Restrictions:
Restricted to use on the advice of microbiologists or infectious disease physicians when laboratory results indicate sensitivity and according to local treatment protocols where applicable.
- The NHSGGC acute care and primary care protocols click here
Prescribing Notes:
Formulary indications:
- Treatment of extended-spectrum beta-lactamases (ESBL) lower urinary tract infection (LUTI) in non-septic men as an oral alternative to current intravenous treatments.
- Treatment of extended-spectrum beta-lactamases (ESBL) lower urinary tract infection (LUTI) in non-pregnant women as an oral alternative to current intravenous treatments.
- Treatment of acute lower uncomplicated urinary tract infections, caused by pathogens sensitive to fosfomycin in adult and adolescent females.
- Prophylactic treatment in diagnostic and surgical transurethral procedures.
Restrictions:
Restricted to use only on the advice of a microbiologist or infectious disease physician for multi-resistant organisms.
Prescribing Notes:
Please note: the IV FORM of fosfomycin is a PROTECTED ANTIBIOTIC (see policy here) and relevant paperwork should be completed.
Restrictions:
Restricted to specialist use only. Restricted to hospital-based use on the advice of a microbiologist or infectious disease physician. Prolonged use (>2 weeks) must be avoided.
Prescribing Notes:
Access Linezolid treatment protocol and discharge & outpatient checklist by clicking the hyperlinks.
Please note: this is a PROTECTED ANTIBIOTIC (see policy here) and relevant paperwork should be completed.
Restrictions:
Not to be used in patients with structural urological abnormalities or indwelling catheters.
Prescribing Notes:
Can be as an antibiotic-sparing treatment option in pre-and post-menopausal women with recurrent UTIs alongside measures recommended by NHS.
Restrictions:
Use 550mg tablets for the reduction in recurrence of episodes of overt hepatic encephalopathy (HE) in patients ≥18 years of age is restricted to initiation by a consultant gastroenterologist.
Prescribing Notes:
Rifaximin is considered to be most useful in a highly selective group of patients with hepatic encephalopathy who are resistant to other standard therapies such as lactulose and dietary measures.
Restrictions:
Restricted to use only on the advice of microbiologists and specialists in infectious diseases for use in patients with ABSSSI caused by Gram-positive Staphylococcus aureus (specifically methicillin-resistant Staphylococcus aureus [MRSA] isolates) as an alternative oxazolidinone antibacterial.
Please note: this is a PROTECTED ANTIBIOTIC (see policy here) and relevant paper work should be completed.
Restrictions:
Restricted to specialist initiation. Restricted to use on microbiological and infectious disease physician advice only. Vancomycin is the first line glycopeptide.
Restrictions:
Restricted to specialist initiation. Restricted to use on microbiological and infectious disease physician advice only. Vancomycin is the first line glycopeptide.