6.4. Sex hormones
6.4.1. Female sex hormones
220.127.116.11. Oestrogens and HRT
Contains estradiol 1mg.
This formulation contains 1.53mg/spray of estradiol.
Used for the short-term treatment of symptoms of oestrogen deficiency, tibolone is not suitable for use in the pre-menopausal stage or within 12 months of the last menstrual period (unless being treated with gonadotrophin releasing hormone analogues).
Estradiol and dydrogesterone.
Combination of Evorel® 50 patches (containing estradiol) and Evorel® Conti patches (estradiol and norethisterone acetate).
Available as 1/10 and 2/10 strengths. Contains estradiol and dydrogesterone.
Available as estradiol 1mg or 2mg with norethisterone 1mg.
Transdermal patch containing estradiol. Available in 25, 50, 75 and 100 micrograms/24hour strengths.
Restrictions: Restricted to specialist initiation. Restricted to use in patients for whom bisphosphonates are contraindicated or not appropriate.
Restrictions: Restricted to patients who fail to tolerate oral or patch preparations.
The treatment of moderate to severe symptoms of uterine fibroids in adult women is restricted to the following MHRA advice:
- intermittent treatment of moderate to severe symptoms of uterine fibroids in women of reproductive age who are not eligible for surgery or where surgery has failed
- treatment is to be initiated and supervised by a physician experienced in the diagnosis and treatment of uterine fibroids
Please refer to MHRA information prior to initiation.
6.4.2. Male sex hormones and antagonists
Restrictions: Restricted to specialist initiation.
All testosterone preparations are restricted to specialist initiation. In addition, testosterone transdermal gel is restricted to use on the recommendation of consultant endocrinologists, urologists and oncologists for patients requiring a transdermal delivery system.
6.4.3. Anabolic steroids
Restrictions: Restricted to specialist use only.