Greater Glasgow and Clyde Medicines
Key to symbols The medicine should be initiated by, or on the advice of a specialist, but is suitable for continuation by a GP The medicine should only be used and prescribed by a specialist Indicates the preferred choice within a class or group of medicines
The medicine should be initiated by, or on the advice of a specialist, but is suitable for continuation by a GP
The medicine should only be used and prescribed by a specialist
Indicates the preferred choice within a class or group of medicines
6.4.1. Female sex hormones

6.4.1.1. Oestrogens and HRT

6.4.1.1.1. Combination products

For use in women with an intact uterus

6.4.1.1.1.1. Sequential combined therapy (cyclical)

Last menstrual period <1 year ago

Preferred List
ELLESTE DUET

Prescribing Notes:

Tablet containing estradiol 1mg or 2mg with norethisterone 1mg.

BNF Link

EVOREL SEQUI

Prescribing Notes:

Combination of Evorel® 50 patches (containing estradiol) and Evorel® Conti patches (estradiol and norethisterone acetate).

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FEMOSTON

Prescribing Notes:

Tablet available as 1mg/10mg and 2mg/10mg strengths. Contains estradiol and dydrogesterone.

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6.4.1.1.1.2. Continuous combined therapy

Last menstrual period >1 year ago

Preferred List
ELLESTE DUET CONTI

Prescribing Notes:

Tablet containing estradiol 2mg and norethisterone acetate 1mg.

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EVOREL CONTI

Prescribing Notes:

Transdermal patch containing estradiol 50mcg /24 hours and norethisterone acetate 170mcg / 24 hours.

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FEMOSTON-CONTI

Prescribing Notes:

Tablet available as 0.5mg/2.5mg and 1mg/5mg strengths. Contains estradiol and dydrogesterone.

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KLIOVANCE

Prescribing Notes:

Tablet containing estradiol 1mg and norethisterone acetate 0.5mg.

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Total Formulary
ESTRADIOL WITH MICRONISED PROGESTERONE (BIJUVE)

Prescribing Notes:

Capsule containing estradiol 1mg and progesterone 100mg.

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6.4.1.1.2. Oestrogen only

For use in women with no uterus or using an alternative progesterone

Preferred List
Preferred List First Line
ELLESTE SOLO

Prescribing Notes:

Tablet containing estradiol 1mg.

BNF Link

EVOREL

Prescribing Notes:

Transdermal patch containing estradiol. Available in 25, 50, 75 and 100 micrograms/24hour strengths.

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LENZETTO (TRANSDERMAL SPRAY)

Prescribing Notes:

This formulation contains 1.53mg/spray of estradiol.

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Total Formulary
ESTRADOT

Prescribing Notes:

Transdermal patch containing estradiol. Available in 25, 37.5, 50, 75 and 100 micrograms/24hour strengths.

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OESTROGEL (GEL)

Restrictions:

Restricted to patients who fail to tolerate oral or patch preparations.

Prescribing Notes:

Strength: 0.06%

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6.4.1.1.3. Gonadomimetic

Preferred List
TIBOLONE

Prescribing Notes:

Tablets used for the short-term treatment of symptoms of oestrogen deficiency. Unsuitable for use in the premenopause (unless being treated with gonadotrophin-releasing hormone analogue) and as (or with) an oral contraceptive. Also unsuitable for use within 12 months of last menstrual period (may cause irregular bleeding).

If transferring from cyclical HRT, start at end of regimen; if transferring from continuous-combined HRT, start at any time.

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