NHS Greater Glasgow & Clyde Area Drug and Therapeutics Committee
Greater Glasgow and Clyde Prescribing
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1 Gastro-intestinal system

1.2 Antispasmodics and other drugs altering gut motility

Other than in the early phase of irritable bowel disease, the place in therapy of antispasmodics is questionable. Reassurance, diet, fluids, exercise, bulking agents and lifestyle modifications achieve best results

Preferred list

Prescribing Notes:

In April 2014, following a Europe-wide review, the MHRA issued advice to healthcare professionals relating to the use of domperidone, restricting its use to relief or nausea and vomiting, advising that it should be used at the lowest effective dose for the shortest possible time, and highlighting changes to the contraindications, dosing and duration of treatment of the medicine.

The full advice from the MHRA can be accessed here.


BNF Link: http://www.medicinescomplete.com/mc/bnf/current/2107.htm


Restrictions: Excludes modified-release preparations

Prescribing Notes:

Where possible, the tablets should be used as the oral suspension is significantly more expensive

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/2100.htm?q=mebeverine&t=search&ss=text&p=2#_hit

Total Formulary

Restrictions: Restricted to initiation by, or on advice of, a specialist.

BNF Link: http://www.medicinescomplete.com/mc/bnf/current/2083.htm